Abstract | BACKGROUND: Henoch-Schönlein purpura (HSP) can progress to Henoch-Schönlein purpura nephritis (HSPN), and the most effective management remains unclear. Our aim was to evaluate the efficacy of mycophenolate mofetil (MMF) for treating pediatric patients with HSPN and nephrotic-range proteinuria. METHODS: Twelve children, seven boys and five girls, mean age 8.33 (range 6-12) years at the time of HSPN diagnosis with nephrotic-range proteinuria, were treated with MMF. All patients failed steroid treatment, and mean proteinuria at the time of MMF initiation was 5.6 g/d. MMF dosage ranged from 20 to 25 mg/kg per day. Patients also received an angiotensin-converting enzyme inhibitor (cliazapril) at MMF initiation. Mean follow-up was 3.9 (range 2.3-5.5) years. RESULTS: All patients responded to MMF at a mean of 2.5 (range 1-4 months). Among the 12 patients, MMF was administered for 10 months in five, 12 months in six, and 15 months in one. At last follow-up, all patients had negative proteinuria and normal renal function, and no relapses were noted. No serious adverse effects of MMF were noted in any patient. CONCLUSION: MMF is useful for treating pediatric patients with HSPN and nephrotic-range proteinuria.
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Authors | Yue Du, Ling Hou, Chengguang Zhao, Mei Han, Yubin Wu |
Journal | Pediatric nephrology (Berlin, Germany)
(Pediatr Nephrol)
Vol. 27
Issue 5
Pg. 765-71
(May 2012)
ISSN: 1432-198X [Electronic] Germany |
PMID | 22081165
(Publication Type: Journal Article)
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Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Immunosuppressive Agents
- Steroids
- Cyclophosphamide
- Mycophenolic Acid
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Topics |
- Angiotensin-Converting Enzyme Inhibitors
(therapeutic use)
- Biopsy
- Child
- Cyclophosphamide
(therapeutic use)
- Drug Resistance
- Female
- Follow-Up Studies
- Humans
- IgA Vasculitis
(complications, therapy)
- Immunosuppressive Agents
(therapeutic use)
- Kidney
(pathology)
- Kidney Function Tests
- Leukocyte Count
- Male
- Mycophenolic Acid
(analogs & derivatives, therapeutic use)
- Nephritis
(etiology, therapy)
- Proteinuria
(etiology)
- Retrospective Studies
- Steroids
(therapeutic use)
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