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Potential use of D-glucaric acid derivatives in cancer prevention.

Abstract
There is now growing evidence from animal models for the possible control of different stages of the carcinogenic process by the beta-glucuronidase inhibitor D-glucaro-1,4-lactone and its precursors such as D-glucaric acid salts, D-glucarates. D-Glucaric acid is a natural, non-toxic compound produced in small amounts by mammals, including humans. It was recently found in some vegetables and fruits. D-Glucaro-1,4-lactone and D-glucarate exhibit potent antiproliferative properties in vivo. Some human subpopulations could have reduced risk of cancer development by ingesting food rich in D-glucaric acid or self-medication with D-glucarates alone or in combination with other chemopreventive agents.
AuthorsZ Walaszek
JournalCancer letters (Cancer Lett) Vol. 54 Issue 1-2 Pg. 1-8 (Oct 08 1990) ISSN: 0304-3835 [Print] Ireland
PMID2208084 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review)
Chemical References
  • Glucuronidase
  • Glucaric Acid
Topics
  • Animals
  • Diet
  • Glucaric Acid (administration & dosage, analogs & derivatives)
  • Glucuronidase (antagonists & inhibitors)
  • Humans
  • Neoplasms, Experimental (prevention & control)

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