HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Relationship of 4F2 antigen with local growth and metastatic potential of squamous cell carcinoma of the larynx.

Abstract
The 4F2 antigen is a cell-membrane glycoprotein which arises early in the G0-G1 phases of the cell cycle. This molecule is present in all established human cell lines and most malignant human cells. The authors used an indirect immunophosphatase method to study 50 squamous cell carcinomas of the larynx and ten lymph-node metastases, corresponding to six primary tumors, for 4F2 expression. The tumors showed several patterns of 4F2 staining which were correlated with different behaviors and prognoses of the neoplasms. Three different patterns (no staining, peripheral staining, and diffuse 4F2 expression) are described as are their relationships with metastatic behavior of the carcinomas. Tumors with metastases were found only in the third group (P = 0.0001). These results led to the following conclusions: (1) the 4F2 antigen is present in squamous cell carcinomas; (2) its distribution reflects the tumor-spreading pattern; and (3) it correlates with differentiation and metastatic behavior.
AuthorsF Esteban, F Ruiz-Cabello, A Concha, M Perez Ayala, M Delgado, F Garrido
JournalCancer (Cancer) Vol. 66 Issue 7 Pg. 1493-8 (Oct 01 1990) ISSN: 0008-543X [Print] United States
PMID2208000 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Monoclonal
  • Antigens, Neoplasm
  • Antigens, Surface
  • Fusion Regulatory Protein-1
Topics
  • Antibodies, Monoclonal
  • Antigens, Neoplasm (analysis)
  • Antigens, Surface (analysis)
  • Carcinoma, Squamous Cell (immunology, secondary)
  • Fusion Regulatory Protein-1
  • Humans
  • Immunoenzyme Techniques
  • Laryngeal Neoplasms (immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: