Abstract | PURPOSE: METHODS: This comparative, controlled, prospective study conducted over a period of 10 months examined 52 eyes of 52 patients with (a) treatment with SDM at the active leakage site guided by fluorescein angiography (FA) (n=16 eyes), (b) intravitreal injection of 1.25 mg BCZ (n=10 eyes), or (c) observation (n=26 eyes). Outcome measures included changes in retinal pigment epithelium (RPE) leakage at FA, central macular thickness (CMT), best-corrected visual acuity (BCVA), and 10° macular perimetry. RESULTS: At the end of the study, there was 12.5% persistent leakage in the SDM, compared with 60% in the BCZ and 92% in the control group. Mean CMT decreased by 94 μm in the SDM, 38 μm in the BCZ, and did not change in the control group. Mean BCVA improved more than 6 early treatment of diabetic retinopathy study letters in the SDM, decreased by one letter in the BCZ, and by two letters in the control group. In the SDM group, mean perimetric deficit improved by 1.5 decibels and corrected lost variance by 2.6. In the BCZ, it improved by 0.6, and in the control group by 0.5. Retreatment was required in 7/16 eyes of the SDM group (43.75%), and in 5/10 eyes of the BCZ group (50%). CONCLUSION:
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Authors | M J Koss, I Beger, F H Koch |
Journal | Eye (London, England)
(Eye (Lond))
Vol. 26
Issue 2
Pg. 307-14
(Feb 2012)
ISSN: 1476-5454 [Electronic] England |
PMID | 22079961
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiogenesis Inhibitors
- Antibodies, Monoclonal, Humanized
- Bevacizumab
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Topics |
- Adult
- Angiogenesis Inhibitors
(administration & dosage)
- Antibodies, Monoclonal, Humanized
(administration & dosage)
- Bevacizumab
- Central Serous Chorioretinopathy
(physiopathology, therapy)
- Female
- Fluorescein Angiography
- Humans
- Intraocular Pressure
(physiology)
- Intravitreal Injections
- Laser Coagulation
(methods)
- Lasers, Semiconductor
(therapeutic use)
- Macula Lutea
(physiopathology)
- Male
- Middle Aged
- Prospective Studies
- Retinal Pigment Epithelium
(physiopathology)
- Visual Acuity
(physiology)
- Visual Fields
(physiology)
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