Abstract | BACKGROUND: This study was conducted to evaluate and analyze the efficacy and safety of using gemeprost for second- and third-trimester termination of pregnancy (TOP) in women with uterine scar due to previous cesarean section. STUDY DESIGN: RESULTS: One hundred eleven women with one (89.2%) or two (10.8%) previous cesarean sections underwent medical TOP with gemeprost. The median induction-to-expulsion interval was 18 h 24 min (range, 2 h 20 min-168 h 28 min), and in 34 (30.6%) cases, the induction interval was longer than 24 h. The overall incidence of severe complications was 9/111 (8.1%), including one case of silent uterine rupture (with the need for blood transfusion), four cases of atonic and three secondary hemorrhages and one case of peritonitis due to uterine perforation during curettage. Failure of induction (induction-to-expulsion >48 h) occurred in 11 cases (9.9%). CONCLUSION:
Gemeprost-induced TOP in the second and third trimester in women with uterine scar due to previous cesarean section is effective and has a low complication rate.
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Authors | Christian M Domröse, Annegret Geipel, Christoph Berg, Henning Lorenzen, Ulrich Gembruch, Arne Willruth |
Journal | Contraception
(Contraception)
Vol. 85
Issue 6
Pg. 589-94
(Jun 2012)
ISSN: 1879-0518 [Electronic] United States |
PMID | 22079607
(Publication Type: Journal Article)
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Copyright | Crown Copyright © 2012. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Abortifacient Agents, Nonsteroidal
- gemeprost
- Alprostadil
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Topics |
- Abortifacient Agents, Nonsteroidal
(administration & dosage)
- Abortion, Induced
(methods)
- Adult
- Alprostadil
(administration & dosage, adverse effects, analogs & derivatives)
- Cesarean Section
(adverse effects)
- Cicatrix
(complications)
- Female
- Gestational Age
- Humans
- Pregnancy
- Retrospective Studies
- Uterine Diseases
(complications)
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