Cytotoxic and antimicrobial aporphine alkaloids from Fissistigma poilanei (Annonaceae) collected in Vietnam.

Abstract

Two new aporphine alkaloids: 8-hydroxy-9-methoxy-1,2-methylenedioxyaporphine (1) and 8-hydroxy-3,9-dimethoxy-1,2-methylenedioxyaporphine (2) were isolated from the ethyl acetate extract of Fissistigma poilanei along with five known compounds: oxocrebanine (3), kuafumine (4), (2R,3R)-3',4',5,7-tetrahydroxydihydroflavonol-3-O-α-L-rhamnopyranoside (5), (+)-catechin 3-O-α-L-rhamnopyranoside (6) and quercetine 3,7-dimethoxy-3'-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyranoside (7). These two new aporphine alkaloids exhibited a moderate cytotoxic activity against four human cancer cell lines (KB, Hep-G2, MCF-7, LU) as well as antimicrobial activity against Lactobacillus fermentum, Enterococcus faecium, Staphylococcus aureus and Bacillus subtillis.

• Authors: Tran Thi Thanh Thuy, Tran Duc Quan, Nguyen Thi Hoang Anh, Tran Van Sung
• Journal: Natural product research (Nat Prod Res) Vol. 26 Issue 14 Pg. 1296-302 ( 2012) ISSN: 1478-6427 [Electronic] England
• PMID: 22077457 (Publication Type: Journal Article)

Chemical References

• Alkaloids
• Anti-Infective Agents
• Antineoplastic Agents
• Aporphines
• aporphine

Topics

• Alkaloids (chemistry, pharmacology)
• Annonaceae (chemistry)
• Anti-Infective Agents (chemistry, pharmacology)
• Antineoplastic Agents (chemistry, pharmacology)
• Aporphines (chemistry, pharmacology)
• Bacillus subtilis (drug effects)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Enterococcus faecium (drug effects)
• Hep G2 Cells
• Humans
• Limosilactobacillus fermentum (drug effects)
• Staphylococcus aureus (drug effects)
• Vietnam