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Serum soluble CD26 levels: diagnostic efficiency for atopic dermatitis, cutaneous T-cell lymphoma and psoriasis in combination with serum thymus and activation-regulated chemokine levels.

AbstractBACKGROUND:
CD26 is a multifunctional type II transmembrane glycoprotein, which also exists as a secreted isoform, soluble CD26 (sCD26). The CD26 expression on circulating T cells is decreased in some skin diseases such as cutaneous T-cell lymphoma (CTCL) and psoriasis. It remains to be determined whether sCD26 can be used as a marker of skin diseases or not.
OBJECTIVE:
To investigate utility of sCD26 as a diagnostic marker of skin diseases in combination with thymus and activation-regulated chemokine (TARC).
METHODS:
Serum sCD26 levels were measured using enzyme-linked immunosorbent assay in 130 participants including 32 patients with atopic dermatitis (AD); 45 patients with CTCL; 26 patients with psoriasis; and 27 healthy controls.
RESULTS:
Serum sCD26 levels in patients with CTCL and psoriasis (162.1 ± 80.2 ng/mL and 125.4 ± 82.1 ng/mL respectively) were significantly lower than those of healthy controls (392.6 ± 198.7 ng/mL; P < 0.01 and 0.01 respectively). In patients with CTCL, serum sCD26 levels of patients with advanced stage were 135.0 ± 51.5 ng/mL and they were significantly lower than those with early stage (193.1 ± 96.0 ng/mL; P < 0.05). When we used serum sCD26 and TARC levels for diagnostic criteria, sensitivity, specificity, positive predictive value and negative predictive value for AD, CTCL and psoriasis were 65.2-73.7%, 81.4-97.6%, 65.2-94.4%, and 81.4-88.9% respectively.
CONCLUSION:
Serum sCD26 levels, combined with serum TARC levels, are helpful in diagnosis of AD, CTCL and psoriasis.
AuthorsT Miyagaki, M Sugaya, H Suga, S Morimura, M Kamata, H Ohmatsu, H Fujita, Y Asano, Y Tada, T Kadono, S Sato
JournalJournal of the European Academy of Dermatology and Venereology : JEADV (J Eur Acad Dermatol Venereol) Vol. 27 Issue 1 Pg. 19-24 (Jan 2013) ISSN: 1468-3083 [Electronic] England
PMID22077186 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Copyright© 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology.
Chemical References
  • Biomarkers
  • Chemokine CCL17
  • Dipeptidyl Peptidase 4
Topics
  • Adult
  • Biomarkers (blood)
  • Case-Control Studies
  • Chemokine CCL17 (blood, metabolism)
  • Dermatitis, Atopic (blood, diagnosis, physiopathology)
  • Dipeptidyl Peptidase 4 (blood, metabolism)
  • Disease Progression
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Lymphoma, T-Cell, Cutaneous (blood, diagnosis, physiopathology)
  • Male
  • Middle Aged
  • Psoriasis (blood, diagnosis, physiopathology)
  • Reference Values
  • Risk Assessment
  • Sensitivity and Specificity
  • Severity of Illness Index
  • Solubility

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