DNA topoisomerase II alpha: a favorable prognostic factor in colorectal caner.

Abstract

PURPOSE:

There is a lack of study concerning expression of Topoisomerase IIα (Topo IIα) and long-term results in colorectal cancer patients. We aimed to investigate the relationship between expression of Topo IIα and clinicopathological parameters including overall survival in colorectal cancer.

METHODS:

Paraffin-fixed specimens from a large prospective cohort of colorectal cancer patients who had been followed up for 4 years were assayed immunohistochemically.

RESULTS:

Of 490 colorectal cancer patients accessible for Topo IIα expression, expression of Topo IIα was scored as (-) in 4 (0.8%) patients, (+) in 41 (8.4%) patients, (++) in 396 (80.8%) patients, and (+++) in 49 (10.0%) patients. Overexpression of Topo IIα was found to be related with lower T stage (p = 0.042), lower N stage (p = 0.038), and a lower incidence of recurrence with nearly significance (p = 0.053). Kaplan-Meier analyses showed that overexpression of Topo IIα was related with prolonged overall survival (p = 0.022) and disease-free survival (p = 0.036). Multivariate analyses showed that elevated serum CEA (p < 0.001), elevated serum CA199 (p = 0.002), poor differentiation (p = 0.001), advanced Dukes stage (p < 0.001), and lower expression of Topo IIα (p = 0.017) were independent predictive factors for poor prognosis.

CONCLUSIONS:

Topo IIα expression is a valuable prognostic indicator for colorectal cancer and would be useful in treatment selection for early colorectal cancer and malignant colorectal polyps resected under endoscopy, especially when it is used in combination with serum CEA, CA199, and differentiation.

• Authors: Xian Hua Gao, Zhi Qi Yu, Chang Zhang, Chen Guang Bai, Jian Ming Zheng, Chuan Gang Fu
• Journal: International journal of colorectal disease (Int J Colorectal Dis) Vol. 27 Issue 4 Pg. 429-35 (Apr 2012) ISSN: 1432-1262 [Electronic] Germany
• PMID: 22076611 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, Neoplasm
• DNA-Binding Proteins
• DNA Topoisomerases, Type II

Topics

• Aged
• Antigens, Neoplasm (metabolism)
• Colorectal Neoplasms (enzymology, pathology)
• DNA Topoisomerases, Type II (metabolism)
• DNA-Binding Proteins (metabolism)
• Disease-Free Survival
• Female
• Humans
• Intestinal Mucosa (enzymology, pathology)
• Male
• Middle Aged
• Multivariate Analysis
• Proportional Hazards Models