Abstract | PURPOSE:
Eupatilin is an antioxidative flavone and a phytopharmaceutical derived from Artemisia asiatica. It has been reported to possess anti- tumor activity in some types of cancer including gastric cancer. Eupatilin may modulate the angiogenesis pathway which is part of anti-inflammatory effect demonstrated in gastric mucosal injury models. Here we investigated the anti- tumor effects of eupatilin on gastric cancer cells and elucidated the potential underlying mechanism whereby eupatilin suppresses angiogenesis and tumor growth. MATERIALS AND METHODS: RESULTS:
Eupatilin significantly reduced VEGF, ARNT and STAT3 expression prominently under hypoxic conditions. The recruitment of STAT3, ARNT and HIF-1α to the VEGF promoter was inhibited by eupatilin treatment. HUVECs produced much foreshortened and severely broken tubes with eupatilin treatment. In addition, eupatilin effectively reduced tumor growth in a mouse xenograft model. CONCLUSIONS:
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Authors | Jae-Ho Cheong, Sung Yi Hong, Yanjun Zheng, Sung Hoon Noh |
Journal | Journal of gastric cancer
(J Gastric Cancer)
Vol. 11
Issue 1
Pg. 16-22
(Mar 2011)
ISSN: 2093-5641 [Electronic] Korea (South) |
PMID | 22076197
(Publication Type: Journal Article)
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