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Vaginal diazepam use with urogenital pain/pelvic floor dysfunction: serum diazepam levels and efficacy data.

Abstract
Vaginal diazepam is used off-label for pelvic floor dysfunction and urogenital pain, but serum levels with efficacy have not been reported until now. One clinician evaluated 21 women for overall, levator, and vulvar pain pre- and one-month post-daily diazepam treatment. One-month post-treatment assessments and serum diazepam levels were done; 62% were moderately or markedly improved. Levator examination pain scores were significantly improved, and vulvar pain scores decreased post-treatment. Serum diazepam levels were within normal limits. Vaginal diazepam may be helpful in treating pelvic floor/urogenital pain conditions.
AuthorsDonna J Carrico, Kenneth M Peters
JournalUrologic nursing (Urol Nurs) 2011 Sep-Oct Vol. 31 Issue 5 Pg. 279-84, 299 ISSN: 1053-816X [Print] United States
PMID22073898 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Muscle Relaxants, Central
  • Diazepam
Topics
  • Administration, Intravaginal
  • Adult
  • Diazepam (administration & dosage, blood)
  • Female
  • Humans
  • Middle Aged
  • Muscle Relaxants, Central (administration & dosage, blood)
  • Pelvic Floor Disorders (complications, nursing)
  • Pelvic Pain (drug therapy, etiology, nursing)
  • Treatment Outcome
  • Young Adult

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