Relationships between tumour necrosis factor-α, interleukin-12B and interleukin-10 gene polymorphisms and hepatitis B in Chinese Han haemodialysis patients.

Abstract

AIM:

To investigate the possible association of gene polymorphisms of tumour necrosis factor (TNF)-α (-238 and -308), interleukin (IL)-10 (-592 and -819) and 3' untranslated region (3'UTR) of the IL12B (-1188) and hepatitis B in Chinese Han haemodialysis (HD) patients.

METHODS:

The genotyping of TNF-α -238 and -308, IL-10 -592 and -819 and 3'UTR of the IL12B were performed by polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) method.

RESULTS:

The TNF-α-238 A allele, the IL12B 3'UTR C/C, C/A genotypes were associated with decreased susceptibility to hepatitis B viral infection (P = 0.047, P = 0.003 and P = 0.001 respectively). The frequencies of IL-10-592 A/A genotype, IL-10-819 T/T genotype were lower in the HBV persistence group (P = 0.029 and P = 0.019) than those in the virus clearance group.

CONCLUSIONS:

TNF-α and IL12B 3'UTR gene polymorphisms may be associated with HBV susceptibility and IL-10 gene polymorphisms may be related to the HBV persistence infection in Chinese Han HD patients.

• Authors: Cuiyu Wang, Xiaoli Zhang, Bei Zhu, Dalan Hu, Jianqing Wu, Rongbin Yu, Weihong Zhao
• Journal: Nephrology (Carlton, Vic.) (Nephrology (Carlton)) Vol. 17 Issue 2 Pg. 167-74 (Feb 2012) ISSN: 1440-1797 [Electronic] Australia
• PMID: 22070668 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2011 The Authors. Nephrology © 2011 Asian Pacific Society of Nephrology.

Chemical References

• 3' Untranslated Regions
• IL10 protein, human
• IL12B protein, human
• Interleukin-12 Subunit p40
• Tumor Necrosis Factor-alpha
• Interleukin-10

Topics

• 3' Untranslated Regions
• Adult
• Aged
• Asian People (genetics)
• Chi-Square Distribution
• China (epidemiology)
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Hepatitis B (diagnosis, ethnology, genetics, immunology)
• Hepatitis B virus (pathogenicity)
• Humans
• Interleukin-10 (genetics)
• Interleukin-12 Subunit p40 (genetics)
• Logistic Models
• Male
• Middle Aged
• Multivariate Analysis
• Odds Ratio
• Polymorphism, Genetic
• Renal Dialysis
• Risk Assessment
• Risk Factors
• Tumor Necrosis Factor-alpha (genetics)