Clinical effects of long-term metreleptin treatment in patients with lipodystrophy.

Abstract

OBJECTIVE:

To evaluate the long-term clinical effect of treatment with metreleptin (an analogue of human leptin) on glycemic and lipid abnormalities and markers of hepatic steatosis in patients with inherited or acquired lipodystrophy.

METHODS:

Fifty-five patients (36 with generalized lipodystrophy and 19 with partial lipodystrophy) with at least 1 of 3 metabolic abnormalities (diabetes mellitus, fasting triglyceride level ≥200 mg/dL, and insulin resistance) and low leptin levels received subcutaneous injections of metreleptin once or twice daily in an ongoing clinical trial at the National Institutes of Health.

RESULTS:

At baseline, hemoglobin A1c-8.5% ± 2.1% (mean ± standard deviation [SD])-and triglycerides-479 ± 80 mg/dL (geometric mean ± standard error [SE])-were substantially elevated. Robust and sustained reductions in both variables were evident for the observed patient population during a 3-year metreleptin treatment period (-2.1% ± 0.5% [mean ± SE] and -35.4% ± 13.7% [mean ± SE], respectively). Mean alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were elevated at baseline (100 ± 120 U/L and 71 ± 77 U/L [mean ± SD], respectively) and decreased by -45 ± 19 U/L and -33 ± 14 U/L (mean ± SE), respectively, during the 3-year metreleptin treatment period. Improvements in hemoglobin A1c, triglycerides, ALT, and AST were more pronounced in the subsets of patients having elevated levels at baseline. The most notable adverse events observed in this patient population were likely attributable to underlying metabolic abnormalities or comorbidities.

CONCLUSION:

Metreleptin treatment substantially reduced glycemic variables, triglycerides, and liver enzymes (ALT and AST) and demonstrated durability of response throughout a 3-year treatment period. These results support metreleptin as a potential treatment for certain metabolic disorders (for example, diabetes mellitus and hypertriglyceridemia) associated with lipodystrophy.

• Authors: Jean L Chan, Karen Lutz, Elaine Cochran, Wenying Huang, Yvette Peters, Christian Weyer, Phillip Gorden
• Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists (Endocr Pract) 2011 Nov-Dec Vol. 17 Issue 6 Pg. 922-32 ISSN: 1934-2403 [Electronic] United States
• PMID: 22068254 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Biomarkers
• Glycated Hemoglobin A
• Hypoglycemic Agents
• Hypolipidemic Agents
• Leptin
• hemoglobin A1c protein, human
• metreleptin

Topics

• Adolescent
• Adult
• Aged
• Biomarkers (blood)
• Child
• Cohort Studies
• Fatty Liver (etiology, prevention & control)
• Female
• Glycated Hemoglobin (analysis)
• Humans
• Hypertriglyceridemia (etiology, prevention & control)
• Hypoglycemic Agents (adverse effects, therapeutic use)
• Hypolipidemic Agents (adverse effects, therapeutic use)
• Leptin (adverse effects, analogs & derivatives, therapeutic use)
• Lipodystrophy (blood, drug therapy, physiopathology)
• Liver (physiopathology)
• Male
• Middle Aged
• Time Factors
• Young Adult