Evaluation of the humoral immune response in adult dairy cattle three years after vaccination with a bluetongue serotype 8 inactivated vaccine.

Abstract

Despite the widespread use of bluetongue serotype 8 (BTV-8) inactivated vaccines across Europe from 2008 to 2011, two very practical questions remain unanswered about the length of persistence of group-specific antibodies in milk and serum post-vaccination and the duration of protection beyond one year post-vaccination. This study has firstly revealed that group-specific antibodies persist at high levels in milk and serum in the majority of cattle for at least 3 years post-vaccination, thus removing the option of using these animals in ELISA-based surveillance programmes. Secondly neutralising antibodies have been shown to persist in the majority of cattle for at least 3 years post-vaccination, indicating that the cattle are likely to be protected for this time period. This extended duration of protection may have contributed towards the rapid and efficient eradication of BTV-8 from many European countries, despite reducing levels of vaccine coverage.

• Authors: C A L Oura, L Edwards, C A Batten
• Journal: Vaccine (Vaccine) Vol. 30 Issue 2 Pg. 112-5 (Jan 05 2012) ISSN: 1873-2518 [Electronic] Netherlands
• PMID: 22067262 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Ltd. All rights reserved.

Chemical References

• Antibodies, Neutralizing
• Antibodies, Viral
• Vaccines, Inactivated
• Viral Vaccines

Topics

• Animals
• Antibodies, Neutralizing (analysis, blood)
• Antibodies, Viral (analysis, blood)
• Blood (immunology)
• Bluetongue (immunology, prevention & control)
• Bluetongue virus (immunology)
• Cattle
• Europe
• Female
• Follow-Up Studies
• Milk (immunology)
• Time Factors
• Vaccines, Inactivated (administration & dosage, immunology)
• Viral Vaccines (administration & dosage, immunology)