Abstract | OBJECTIVES: METHODS: Forty-eight postmenopausal women with knee pain receiving HRT were enrolled into this open-label, randomized, controlled study. Subjects were randomized into Group 1 (n= 24) or Group 2 (n=24). Subjects in Group 1 were given 3 months open treatment with calcium (260 mg/day) as adjunctive therapy combined with HRT. Group 2 received PPE (9 capsules/day) as adjunctive therapy combined with HRT. Changes in the degree of knee pain were evaluated by the Visual Analog Scale (VAS). RESULTS: Treatment with PPE was significantly effective in reducing the VAS score for knee pain at 4 weeks (p < 0.05), at 8 weeks (p< 0.01) and at 12 weeks (p<0.01), compared with the control group. Interestingly, the effects continued for 4 weeks after cessation of treatment in the PPE group (p< 0.01) compared with the control group. The PPE treatment had no significant adverse effects on blood biochemical and metabolic profiles, especially related to the risk factors for cardiovascular disease. CONCLUSION: PPE is a possible option as an adjunctive oral supplement in the case of HRT-resistant, long-lasting knee pain.
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Authors | K Koike, Y Yamamoto, N Suzuki, R Yamazaki, C Yoshikawa, K Takuma, K Sugiura, M Inoue |
Journal | Climacteric : the journal of the International Menopause Society
(Climacteric)
Vol. 15
Issue 1
Pg. 30-5
(Feb 2012)
ISSN: 1473-0804 [Electronic] England |
PMID | 22066827
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Calcium Compounds
- Placental Extracts
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Topics |
- Aged
- Animal Structures
- Animals
- Arthralgia
(blood, diagnosis, etiology, therapy)
- Calcium Compounds
(administration & dosage)
- Drug Monitoring
- Drug Resistance
- Drug Therapy, Combination
- Female
- Hormone Replacement Therapy
(methods)
- Humans
- Knee Joint
(drug effects, metabolism, physiopathology)
- Middle Aged
- Osteoporosis, Postmenopausal
(blood, complications)
- Pain Measurement
- Placental Extracts
(administration & dosage, adverse effects)
- Swine
(anatomy & histology)
- Treatment Outcome
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