Abstract | BACKGROUND: METHODS: We measured baseline MR-proADM concentrations in 2240 individuals from the prospective AtheroGene study and evaluated the prognostic impact on future fatal and nonfatal cardiovascular events during a follow-up period of 3.6 (1.6) years. RESULTS: The sample comprised 1355 individuals with stable angina pectoris (SAP) and 885 with acute coronary syndrome (ACS). A cardiovascular event occurred in 192 people. Individuals presenting with SAP had only slightly lower plasma MR-proADM concentrations than those with ACS (0.53 vs 0.55 nmol/L, P=0.006). MR-proADM showed a moderate association with age, serum N-terminal pro- B-type natriuretic peptide ( NT-proBNP), glomerular filtration rate, serum C-reactive protein, hypertension, diabetes, and prevalent multivessel disease (all P<0.0005). Individuals suffering from a cardiovascular event had higher MR-proADM concentrations at baseline in both groups (SAP 0.63 vs 0.53 nmol/L and ACS 0.65 nmol/L vs 0.55 nmol/L, both P<0.0005). Cox regression analysis incorporating various variables of cardiovascular risk and NT-proBNP revealed a hazard ratio of 1.4 (95% CI 1.2-1.6; P<0.0005) per increment of MR-proADM by 1SD. In risk models for secondary prevention, MR-proADM provided information comparable to that of NT-proBNP. CONCLUSIONS: MR-proADM is an independent predictor for future cardiovascular events in patients with symptomatic coronary artery disease, providing information comparable to NT-proBNP for secondary risk stratification.
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Authors | Philipp S Wild, Renate B Schnabel, Edith Lubos, Tanja Zeller, Christoph R Sinning, Till Keller, Stergios Tzikas, Karl J Lackner, Dirk Peetz, Hans J Rupprecht, Christoph Bickel, Nils G Morgenthaler, Jana Papassotiriou, Laurence Tiret, Thomas Münzel, Stefan Blankenberg |
Journal | Clinical chemistry
(Clin Chem)
Vol. 58
Issue 1
Pg. 226-36
(Jan 2012)
ISSN: 1530-8561 [Electronic] England |
PMID | 22065157
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Peptide Fragments
- Protein Precursors
- pro-brain natriuretic peptide (1-76)
- proadrenomedullin
- Natriuretic Peptide, Brain
- Adrenomedullin
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Topics |
- Acute Coronary Syndrome
(diagnosis, mortality, physiopathology)
- Adrenomedullin
(blood)
- Aged
- Angina Pectoris
(diagnosis, mortality, physiopathology)
- Biomarkers
(blood)
- Coronary Artery Disease
(diagnosis, mortality, physiopathology)
- Female
- Humans
- Immunoassay
- Kaplan-Meier Estimate
- Luminescent Measurements
- Male
- Middle Aged
- Natriuretic Peptide, Brain
(blood)
- Peptide Fragments
(blood)
- Predictive Value of Tests
- Prognosis
- Prospective Studies
- Protein Precursors
(blood)
- Risk Assessment
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