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Association between interleukin 21 and Graves' disease.

Abstract
Graves' disease (GD) is an organ-specific autoimmune thyroid disease; 25-50% of GD patients will develop Graves' ophthalmopathy (GO). The etiology of GD and GO may be multifactorial, but the immune response plays a central role. Many studies have reported that IL-21 has crucial roles in autoimmune diseases. We examined whether IL-21 is associated with the development of GD and GO. The serum concentration of IL-21 was tested in 40 primary GD patients, 42 treated GO patients and 24 healthy controls. Our data show that the serum level of IL-21 is associated with the development of GD. We also made an association study with the IL-21 gene polymorphisms rs4833837, rs907715 and rs13143866 in a comparison of 633 patients and 612 healthy controls from the Chinese population. This case-control association study demonstrated that rs907715 SNP is significantly associated with GD, while the rs13143866 A allele is significantly associated with GO. The haplotypes A-G-G and A-A-A were found at higher and lower frequencies, respectively, in GD patients, suggesting a protective role for A-A-A. However, there were no significant differences in the frequencies of these haplotypes between the GO patients and the control group. We found no association between IL-21 gene polymorphisms and the age of GD onset. We conclude that IL-21 is associated with GD and GO.
AuthorsH Y Jia, Z G Zhang, X J Gu, T Guo, B Cui, G Ning, Y J Zhao
JournalGenetics and molecular research : GMR (Genet Mol Res) Vol. 10 Issue 4 Pg. 3338-46 (Oct 31 2011) ISSN: 1676-5680 [Electronic] Brazil
PMID22057994 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Genetic Markers
  • Interleukins
  • interleukin-21
Topics
  • Adolescent
  • Adult
  • Age of Onset
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Child
  • China (epidemiology)
  • Female
  • Genetic Association Studies
  • Genetic Markers
  • Genetic Predisposition to Disease
  • Graves Disease (epidemiology, genetics)
  • Graves Ophthalmopathy (genetics)
  • Haplotypes (genetics)
  • Humans
  • Interleukins (blood, genetics)
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide (genetics)
  • Young Adult

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