Low-grade bone lesions in survivors of childhood medulloblastoma/primitive neuroectodermal tumor.

Abstract

OBJECTIVES AND RATIONALE:

Medulloblastoma/primitive neuroectodermal tumor (MB/PNET) is the most common malignant tumor of the central nervous system (CNS) in children. MB/PNET survivors are at an increased risk for developing second malignancies. Little has been reported on development of low-grade lesions of the calvarium in the radiation field in MB/PNET survivors. The purpose of this study was to assess the frequency of the low-grade bone lesion development in the radiotherapy field in pediatric MB/PNET survivors and describe the imaging characteristics of these lesions.

MATERIALS AND METHODS:

Institutional review board approval was obtained for this retrospective review which was compliant with Health Insurance Portability and Accountability Act. Forty-one MB/PNET patients (29 male) who survived for at least 2 years after initiation of radiation therapy were included. The medical records were reviewed. The most recent available brain magnetic resonance imaging studies were evaluated.

RESULTS:

Three patients (7.3%) developed low-grade calvarial lesions and underwent resection and/or biopsy of the lesions. There were one Langerhans cell histiocytosis, one benign spindle cell lesion with myxoid change, and one fibrous dysplasia.

CONCLUSION:

Development of low-grade bone lesions of calvarium is not very rare in pediatric PNET/MB survivors. Bones in the radiation therapy field need to be carefully examined for assessment of secondary lesions.

• Authors: Korgun Koral, Dave Roy, Charles F Timmons, Lynn Gargan, Daniel C Bowers
• Journal: Academic radiology (Acad Radiol) Vol. 19 Issue 1 Pg. 35-9 (Jan 2012) ISSN: 1878-4046 [Electronic] United States
• PMID: 22054800 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2012 AUR. Published by Elsevier Inc. All rights reserved.

Topics

• Adolescent
• Brain Neoplasms (epidemiology, pathology)
• Child
• Child, Preschool
• Comorbidity
• Female
• Humans
• Incidence
• Infant
• Magnetic Resonance Imaging
• Male
• Medulloblastoma (epidemiology, pathology)
• Neoplasms, Second Primary (epidemiology, pathology)
• Neuroectodermal Tumors, Primitive (epidemiology, pathology)
• Risk Assessment
• Risk Factors
• Skull Neoplasms (epidemiology, pathology)
• Survivors
• Texas (epidemiology)
• Young Adult