Chronic kidney disease, early age-related macular degeneration, and peripheral retinal drusen.

Abstract

PURPOSE:

To evaluate the association between chronic kidney disease (CKD) and early age-related macular degeneration (AMD) and peripheral retinal drusen in Korean adults 50 years and older.

METHODS:

This study included 3008 participants aged 50-87 years. Early AMD was assessed from retinal photographs based on modified Wisconsin AMD grading system and peripheral retinal drusen were assessed with a standardized examination. We defined CKD as estimated glomerular filtration rate of 60mL/min/1.73m(2) and below according to the Modification of Diet in Renal Disease equation. Logistic regression was used to examine the association between early AMD, peripheral retinal drusen, and CKD.

RESULTS:

There were 88 subjects with early AMD and 42 subjects with peripheral retinal drusen. After adjusting for age, gender, body mass index, smoking status, hypertension, and diabetes mellitus, a significant association was found between CKD and peripheral retinal drusen as well as early AMD. Subjects with CKD were more likely to have early AMD (OR, 1.68; 95% CI, 1.04-2.72) and peripheral retinal drusen (OR, 2.01; 95% CI, 1.02-3.99) than those without CKD.

CONCLUSIONS:

CKD was associated with peripheral retinal drusen as well as early AMD in Korean adults 50 years and older.

• Authors: Jaekyung Choi, Jun Woong Moon, Hyun Jin Shin
• Journal: Ophthalmic epidemiology (Ophthalmic Epidemiol) Vol. 18 Issue 6 Pg. 259-63 (Dec 2011) ISSN: 1744-5086 [Electronic] England
• PMID: 22053834 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Aged
• Aged, 80 and over
• Cross-Sectional Studies
• Female
• Humans
• Kidney Failure, Chronic (epidemiology)
• Korea (epidemiology)
• Logistic Models
• Macular Degeneration (epidemiology)
• Male
• Middle Aged
• Retinal Drusen (epidemiology)
• Risk Factors
• Sex Factors
• Visual Fields