HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Analysis of plasma ghrelin in patients with medium-chain acyl-CoA dehydrogenase deficiency and glutaric aciduria type II.

AbstractOBJECTIVE:
Ghrelin requires a fatty acid modification for binding to the GH secretagogue receptor. Acylation of the Ser3 residue of ghrelin is essential for its biological activities. We hypothesized that acyl-CoA is the fatty acid substrate for ghrelin acylation. Because serum octanoyl-CoA levels are altered by fatty acid oxidation disorders, we examined circulating ghrelin levels in affected patients.
MATERIALS AND METHODS:
Blood levels of acyl (A) and des-acyl (D) forms of ghrelin and acylcarnitine of patients with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency and glutaric aciduria type II (GA2) were measured.
RESULTS:
Plasma acyl ghrelin levels and A/D ratios increased in patients with MCAD deficiency or GA2 when compared with normal subjects. Reverse-phase HPLC confirmed that n-octanoylated ghrelin levels were elevated in these patients.
CONCLUSION:
Changing serum medium-chain acylcarnitine levels may affect circulating acyl ghrelin levels, suggesting that acyl-CoA is the substrate for ghrelin acylation.
AuthorsTakashi Akamizu, Nobuo Sakura, Yosuke Shigematsu, Go Tajima, Akira Ohtake, Hiroshi Hosoda, Hiroshi Iwakura, Hiroyuki Ariyasu, Kenji Kangawa
JournalEuropean journal of endocrinology (Eur J Endocrinol) Vol. 166 Issue 2 Pg. 235-40 (Feb 2012) ISSN: 1479-683X [Electronic] England
PMID22048973 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Ghrelin
  • acylcarnitine
  • Acyl-CoA Dehydrogenase
  • Carnitine
Topics
  • Acyl-CoA Dehydrogenase (blood, deficiency, metabolism)
  • Adult
  • Blood Chemical Analysis (methods)
  • Carnitine (analogs & derivatives, analysis, blood)
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Chromatography, High Pressure Liquid
  • Female
  • Ghrelin (analysis, blood, metabolism)
  • Humans
  • Lipid Metabolism, Inborn Errors (blood, metabolism)
  • Multiple Acyl Coenzyme A Dehydrogenase Deficiency (blood, metabolism)
  • Protein Processing, Post-Translational
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: