Abstract |
Blood group NM specificities occur in healthy, benign and carcinomatous breast glands and those of the gastrointestinal (G.I.) tract, but the precursors in their biosynthesis, T (Thomsen-Friedenreich) and Tn, are found in adenocarcinomata and not in benign or healthy tissues. T- and Tn-antigenic specificities are thus human carcinoma-associated. All humans possess anti-T and anti-Tn antibodies. Patients with breast or G.I. tract carcinoma show statistically significant alteration of anti-T titer levels when compared to patients with benign disease and to healthy controls. Breast carcinoma patients but not healthy people showed cellular immunity to T antigen in vitro and in vivo. Most striking was the delayed-type hypersensitivity reaction, which was positive in over 90% of ductal breast carcinoma patients tested and negative in all presumably healthy individuals. T antigen is readily prepared from healthy human red blood cells in uncontaminated form, and free of HL-A and Au antigens. T antigen and anti-T antibodies may be useful in combating some human adenocarcinomata.
|
Authors | G F Springer, P R Desai, M S Murthy, E F Scanlon |
Journal | Journal of surgical oncology
(J Surg Oncol)
Vol. 11
Issue 2
Pg. 95-106
( 1979)
ISSN: 0022-4790 [Print] United States |
PMID | 220469
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S., Review)
|
Chemical References |
- Antibodies, Neoplasm
- Antigens, Neoplasm
- Blood Group Antigens
- MNSs Blood-Group System
|
Topics |
- Adenocarcinoma
(blood)
- Adolescent
- Adult
- Aged
- Antibodies, Neoplasm
- Antigens, Neoplasm
- Blood Group Antigens
- Breast Diseases
(blood)
- Breast Neoplasms
(blood, immunology)
- Carcinoma, Intraductal, Noninfiltrating
(blood)
- Colonic Neoplasms
(blood)
- Female
- Humans
- Immunity, Cellular
- Lung Neoplasms
(blood)
- MNSs Blood-Group System
- Middle Aged
- Stomach Neoplasms
(blood)
|