Abstract |
Thyroid transcription factor 1 (TTF-1) plays a key role in morphogenesis of the lungs and is expressed in up to 90% of pulmonary small cell carcinomas. This explains why this marker is frequently used in the search for the primary origin of metastatic endocrine tumours. Here we report on a TTF-1 expressing mixed endocrine-exocrine carcinoma of the common bile duct in a patient with pulmonary nodules that did not appear to be neoplastic. TTF-1 positivity in pulmonary and extrapulmonary neuroendocrine tumours is reviewed, and we conclude that TTF-1 expression in neuroendocrine tumours of the small-cell type are not uncommon at extrapulmonary locations. Therefore, immunohistochemistry for TTF-1 in such tumours should be interpreted with caution.
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Authors | Laurine Verset, Marianna Arvanitakis, Patricia Loi, Jean Closset, Myriam Delhaye, Myriam Remmelink, Pieter Demetter |
Journal | World journal of gastrointestinal oncology
(World J Gastrointest Oncol)
Vol. 3
Issue 10
Pg. 144-7
(Oct 15 2011)
ISSN: 1948-5204 [Electronic] China |
PMID | 22046491
(Publication Type: Journal Article)
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