Successful therapy with hemoperfusion and plasma exchange in acute 1,2,3-trichloropropane poisoning.

1,2,3-trichloropropane (1,2,3-TCP) is commonly used as an intermediate in pesticide and an industrial specialty solvent. Acute 1,2,3-TCP poisoning is rare but a medical emergency. Sporadic cases of toxic hepatic injury from 1,2,3-TCP in humans have been reported. Liver is a target organ for 1,2,3-TCP toxicity, which may ensue in a short period after ingestion. A specific antidote against 1,2,3-TCP is not available. So it is important to distinguish that a patient with 1,2,3-TCP poisoning constitutes a medical emergency. In this case study, the poisoned patient's clinical condition and laboratory values improved gradually after she received hemoperfusion (HP) and plasma exchange, which indicated that the therapy with HP and plasma exchange were helpful in the treatment of 1,2,3-TCP poisoning.
AuthorsP Liu, Y-G Liang, Q-Y Meng, C-G Zhang, H-C Wang, X-G Zhang, G Li, Z-Y Liu, Y-Z He
JournalHuman & experimental toxicology (Hum Exp Toxicol) Vol. 31 Issue 5 Pg. 523-7 (May 2012) ISSN: 1477-0903 [Electronic] England
PMID22045893 (Publication Type: Case Reports, Journal Article)
Chemical References
  • 1,2,3-trichloropropane
  • Propane
  • Female
  • Hemoperfusion
  • Humans
  • Liver Failure, Acute (chemically induced, therapy)
  • Middle Aged
  • Plasma Exchange
  • Propane (analogs & derivatives, poisoning)

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