Relative efficiency of therapeutic donor insemination using a luteinizing hormone monitor.

Abstract

A prospective randomized study was performed to evaluate the use of a urinary luteinizing hormone (LH) detection kit with 1 insemination as compared with 2 alternate day inseminations with timing based on previous cycle length and basal body temperature changes. The study involved 60 patients who underwent a total of 264 therapeutic donor insemination cycles using cryopreserved semen specimens. Patients alternated LH-kit timed cycles with cycles timed by non-LH methods for a total of 6 cycles or until pregnancy was achieved. Fecundability rates were 12.3% for LH-kit cycles and 5.3% for non-LH method cycles. The difference in outcome was not statistically significant. However, when the LH kit plus 1 insemination was compared with 2 inseminations timed by conventional methods, there appeared to be a distinct monetary and time expenditure advantage. These findings suggest that sufficient advantage may be derived from use of an LH kit to recommend its use on a routine basis for the timing of therapeutic donor insemination.

• Authors: C A Federman, D A Dumesic, W R Boone, S S Shapiro
• Journal: Fertility and sterility (Fertil Steril) Vol. 54 Issue 3 Pg. 489-92 (Sep 1990) ISSN: 0015-0282 [Print] United States
• PMID: 2204553 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Luteinizing Hormone

Topics

• Adult
• Clinical Protocols (standards)
• Female
• Fertility (physiology)
• Humans
• Insemination, Artificial (methods)
• Insemination, Artificial, Heterologous (methods)
• Luteinizing Hormone (urine)
• Menstrual Cycle (physiology, urine)
• Prospective Studies
• Randomized Controlled Trials as Topic
• Time Factors
• Tissue Preservation