Recent progress in understanding the molecular mechanisms of the initiation and progression of
melanoma has created new opportunities for developing novel therapeutic modalities to manage this potentially lethal disease. Although at first glance,
melanoma carcinogenesis appears to be a chaotic system, it is indeed, arguably, a deterministic multistep process involving sequential alterations of proto-oncogenes, tumour suppressors and
miRNA genes. The scope of this article is to discuss the most recent and significant advances in
melanoma molecular
therapeutics. It is apparent that using single agents targeting solely individual
melanoma pathways might be insufficient for long-term survival. However, the outstanding results on
melanoma survival observed with novel selective inhibitors of B-RAF, such as
PLX4032 give hope that
melanoma can be cured. The fact that
melanoma develops acquired resistance to
PLX4032 emphasises the importance of simultaneously targeting several pathways. Because the most striking feature of
melanoma is its unsurpassed ability to metastasise, it is important to implement newer systems for
drug delivery adapted from research on stem cells and nanotechnology.