Comparative photodynamic evaluation of new phenothiazinium derivatives against Propionibacterium acnes.

The screening of recently patented derivatives of the standard phenothiazinium agents methylene blue and toluidine blue was carried out against Propionibacterium acnes, the main bacterium associated with acne vulgaris. Comparative tests were made using the topical agent benzoyl peroxide (BPO) and standard tetracyclines. Each of the photosensitizers employed, including the lead compounds, was photobactericidal at lower concentrations than BPO, and produced a much more rapid kill than the tetracyclines. In addition, the tetracyclic and pentacyclic phenothiazinium derivatives exhibited high light:dark kill ratios, suggesting that these examples might be particularly useful in practice.
AuthorsMark Wainwright, Helen Smalley, Orlanda Scully, Ehsaneh Lotfipour
JournalPhotochemistry and photobiology (Photochem Photobiol) 2012 May-Jun Vol. 88 Issue 3 Pg. 523-6 ISSN: 1751-1097 [Electronic] United States
PMID22043962 (Publication Type: Comparative Study, Journal Article)
Copyright© 2011 Wiley Periodicals, Inc. Photochemistry and Photobiology © 2011 The American Society of Photobiology.
Chemical References
  • Phenothiazines
  • Photosensitizing Agents
  • Drug Evaluation, Preclinical
  • Microbial Sensitivity Tests
  • Phenothiazines (pharmacology)
  • Photochemotherapy
  • Photosensitizing Agents (pharmacology)
  • Propionibacterium acnes (drug effects)

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