Abstract | BACKGROUND:
Clear cell sarcoma is a rare malignant tumor of soft tissue which is most commonly encountered in the extremities, especially in the foot and ankle. This tumor is slow-growing and looks like a benign tumor; it is therefore often treated inadequately and its high rate of recurrence and metastases results in a poor prognosis. Caffeine has been used as a chemotherapy potentiator that inhibits DNA damage repair and enhances the cytocidal effects of anti- cancer drugs. This study reports the effect of caffeine-potentiated chemotherapy for clear cell sarcoma in five patients. METHODS: RESULTS: Four of the eligible patients responded to preoperative chemotherapy. Local recurrence occurred in only one of the five patients. Distant metastasis newly developed in one patient. All five patients survive. CONCLUSION:
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Authors | Michiaki Karita, Hiroyuki Tsuchiya, Norio Yamamoto, Toshiharu Shirai, Katsuhiro Hayashi, Hideji Nishida |
Journal | International journal of clinical oncology
(Int J Clin Oncol)
Vol. 18
Issue 1
Pg. 33-7
(Feb 2013)
ISSN: 1437-7772 [Electronic] Japan |
PMID | 22041928
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Caffeine
- Cisplatin
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Topics |
- Adolescent
- Adult
- Antineoplastic Agents
(administration & dosage)
- Bone Neoplasms
(drug therapy, pathology, surgery)
- Caffeine
(administration & dosage)
- Cisplatin
(administration & dosage)
- DNA Damage
(drug effects)
- DNA Repair
(drug effects)
- Extremities
(pathology, surgery)
- Female
- Humans
- Male
- Middle Aged
- Sarcoma, Clear Cell
(drug therapy, pathology)
- Treatment Outcome
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