Abstract | OBJECTIVE: METHODS: RESULTS: LMP2 and PPM1A protein expressed in cytotrophocytes, syncytiotrophoblast and extravillous trophoblast. The level of LMP2 expression in deteriorative hydatidiform mole was significantly higher than that in non-deteriorative hydatidiform mole or normal chorionic villus (6.79±2.38, 5.26±2.63 and 3.10±1.65, all P<0.01), while there were no difference compared with gestational trophoblastic neoplasms (6.42±2.68, P=0.113). The level of PPM1A expression was highest in normal chorionic villus, and decreased gradually in hydatidiform mole (non-deteriorative and deteriorative) and gestational trophoblastic neoplasms (6.30±2.98, 4.93±2.50, 4.43±2.04 and 3.33±2.06, all P<0.01); the level of PPM1A expression in deteriorative hydatidiform mole was significantly lower than that in non-deteriorative hydatidiform mole (P=0.001). The expression of LMP2 protein was correlated to theca lutein ovarian cyst, the expression of PPM1A protein was related with uterine size (P<0.05). While, there was no correlation between the expressions of the two proteins (P>0.05). CONCLUSIONS: High expression of LMP2 and low expression of PPM1A might play an important role in the motility and invasiveness of trophoblast cells and malignant transformation of hydatidiform mole. Testing the expression of LMP2 and PPM1A in hydatidiform mole tissues of initial uterine evacuation might be have some reference significance in judging outcomes of hydatidiform mole.
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Authors | Sha-sha Zhang, Xiao-yun Wan, Cai-yun Zhou, Wei-guo Lü, Xing Xie |
Journal | Zhonghua fu chan ke za zhi
(Zhonghua Fu Chan Ke Za Zhi)
Vol. 46
Issue 7
Pg. 510-5
(Jul 2011)
ISSN: 0529-567X [Print] China |
PMID | 22041443
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- LMP-2 protein
- PPM1A protein, human
- Phosphoprotein Phosphatases
- Protein Phosphatase 2C
- Cysteine Endopeptidases
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Topics |
- Adolescent
- Adult
- Case-Control Studies
- Chorionic Villi
(metabolism)
- Cysteine Endopeptidases
(metabolism)
- Female
- Gestational Trophoblastic Disease
(metabolism, pathology)
- Humans
- Hydatidiform Mole
(metabolism, pathology)
- Immunohistochemistry
- Middle Aged
- Phosphoprotein Phosphatases
(metabolism)
- Predictive Value of Tests
- Pregnancy
- Protein Phosphatase 2C
- Retrospective Studies
- Trophoblasts
(metabolism)
- Uterine Neoplasms
(metabolism, pathology)
- Young Adult
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