[The evaluation of the therapeutic efficacy of auranofin in juvenile rheumatoid arthritis (the results of Soviet-American research)].

Abstract

The authors describe the results of prospective multicenter Soviet-American placebo-controlled 6-month investigations concerned with assessment of the therapeutic efficacy of auranofin in juvenile rheumatoid arthritis (JRA). 231 patients with JRA were placed under observation. Auranofin was found to be slightly superior to placebo. The drug was tolerated well. It is noted that in the treatment of JRA, of importance are long (6-month) courses of non-steroidal anti-inflammatory drugs.

• Authors: N N Kuz'mina, E Brue, A V Shaĭkov, L A Isaeva, I E Shakhbazian, E Giannini, A A Iakovleva, E P Puodzhiunene, I M Vorontsov, D S Astrauskene
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 62 Issue 5 Pg. 38-41 ( 1990) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Otsenka terapevticheskoĭ éffektivnosti auranofina pri iuvenil'nom revmatoidnom artrite (rezul'taty sovetsko-amerikanskogo issledovaniia).
• PMID: 2204140 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article, Multicenter Study)

Chemical References

• Placebos
• Tablets
• Auranofin

Topics

• Adolescent
• Arthritis, Juvenile (drug therapy)
• Auranofin (adverse effects, therapeutic use)
• Child
• Child, Preschool
• Double-Blind Method
• Humans
• Infant
• Multicenter Studies as Topic
• Placebos
• Prospective Studies
• Tablets
• Time Factors
• USSR
• United States