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Outcome predictors affecting the efficacy of clonazepam therapy for the management of burning mouth syndrome (BMS).

Abstract
BMS is a common condition characterized by chronic oral mucosal pain condition and primarily affects elderly women. Although clonazepam therapy has been widely used due to its efficacy, it is not always effective because of the complexity of BMS pathogenesis. In this study, we have investigated outcome predictors of clonazepam therapy in patients with BMS. One hundred patients with BMS (7 men and 93 women, mean age 58.5 ± 10.8 years) were instructed to take 0.5mg of clonazepam once or twice daily for 4 weeks. The patients were sub-grouped according to psychological status, salivary flow rate, presence of psychiatric medications, symptom area and duration, symptom severity, presence of oral parafunctions, and accompanying oral complaints. The changes in symptoms were analyzed and compared between the sub-groups. Subjects with T-scores ≤50 for each psychological symptom dimension, a greater degree of initial symptoms (visual analog scale (VAS)≥5), and accompanying oral complaints, such as xerostomia and taste disturbance, displayed greater decreases in symptoms compared with their counterparts. In conclusion, psychological status, initial symptom severity, and the presence of xerostomia and/or taste disturbance can serve as outcome predictors of clonazepam therapy for patients with BMS.
AuthorsJi-Young Ko, Moon-Jong Kim, Sang-Goo Lee, Hong-Seop Kho
JournalArchives of gerontology and geriatrics (Arch Gerontol Geriatr) 2012 Nov-Dec Vol. 55 Issue 3 Pg. 755-61 ISSN: 1872-6976 [Electronic] Netherlands
PMID22040716 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Chemical References
  • GABA Modulators
  • Psychotropic Drugs
  • Clonazepam
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Burning Mouth Syndrome (drug therapy, psychology)
  • Clonazepam (therapeutic use)
  • Female
  • GABA Modulators (therapeutic use)
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Psychotropic Drugs (therapeutic use)
  • Salivary Glands (drug effects)
  • Severity of Illness Index
  • Taste Disorders (drug therapy, psychology)
  • Treatment Outcome
  • Xerostomia (drug therapy, psychology)

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