Synthesis of biaryls via AlCl3 catalyzed domino reaction involving cyclization, dehydration, and oxidation.

Abstract

A new chemical access has been developed to synthesize biaryls from substituted acetophenones, phenylacetones, dihydrochalcone, and 2-acetylnaphthalene in reasonably good yields at room temperature via a domino reaction sequence of AlCl(3) catalyzed cyclization, dehydration, and then oxidation.

• Authors: Tadigoppula Narender, Satinath Sarkar, Kandikonda Rajendar, Sriniwas Tiwari
• Journal: Organic letters (Org Lett) Vol. 13 Issue 23 Pg. 6140-3 (Dec 02 2011) ISSN: 1523-7052 [Electronic] United States
• PMID: 22040063 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acetophenones
• Aluminum Compounds
• Biphenyl Compounds
• Chalcones
• Chlorides
• Naphthalenes
• Acetone
• 2-acetylnaphthalene
• Aluminum Chloride

Topics

• Acetone (analogs & derivatives, chemistry)
• Acetophenones (chemistry)
• Aluminum Chloride
• Aluminum Compounds (chemistry)
• Biphenyl Compounds (chemical synthesis, chemistry)
• Catalysis
• Chalcones (chemistry)
• Chlorides (chemistry)
• Combinatorial Chemistry Techniques
• Cyclization
• Dehydration
• Molecular Structure
• Naphthalenes (chemistry)
• Oxidation-Reduction