Immunocompetent cells and epithelial cell modifications in molluscum contagiosum.

Abstract

We studied lesions of molluscum contagiosum with a panel of monoclonal antibodies to determine the phenotype of infiltrating cells and antigen modifications of infected keratinocytes. Our data indicate (1) a complete lack of immunocompetent cells in the viral lesions, and simultaneously a loss of B2-microglobulin reactivity by molluscum bodies, a cellular activation of EGF and transferrin receptors and expression of CD36 antigen of these bodies; (2) a moderate infiltrate of activated T cells and monocytes in the underlying epidermis; (3) an increase of Langerhans cell density and a CD36 expression by the surface of upper layer keratinocytes in the perilesional epidermis.

• Authors: J Viac, Y Chardonnet
• Journal: Journal of cutaneous pathology (J Cutan Pathol) Vol. 17 Issue 4 Pg. 202-5 (Aug 1990) ISSN: 0303-6987 [Print] United States
• PMID: 2203834 (Publication Type: Journal Article)

Chemical References

• HLA-DR Antigens
• Receptors, Transferrin
• beta 2-Microglobulin
• ErbB Receptors

Topics

• Epithelium (immunology, metabolism, microbiology)
• ErbB Receptors (immunology, metabolism)
• HLA-DR Antigens (immunology, metabolism)
• Humans
• Immunohistochemistry
• Keratinocytes (immunology, metabolism, microbiology)
• Langerhans Cells (immunology, metabolism, microbiology)
• Molluscum Contagiosum (immunology, metabolism, pathology)
• Receptors, Transferrin (immunology, metabolism)
• T-Lymphocytes (immunology, metabolism, microbiology)
• beta 2-Microglobulin (immunology, metabolism)