The effects of Lyprinol(®) on delayed onset muscle soreness and muscle damage in well trained athletes: a double-blind randomised controlled trial.

Abstract

OBJECTIVES:

The aim of the study was to determine if Lyprinol(®) is effective in reducing pain, indicators of inflammation and muscle damage, and in turn improving performance in well trained athletes suffering from delayed onset muscle soreness (DOMS).

DESIGN:

A double blind randomised placebo controlled trial.

SETTING:

Twenty well trained male volunteers, matched by VO(2max) were randomly assigned to consume 200mg of Lyprinol(®) or an indistinguishable placebo daily for 8 weeks prior to a downhill treadmill running episode designed to induce DOMS.

MAIN OUTCOME MEASURES:

Performance measures (Kin-Com, counter movement and squat jump), pain assessments (visual analogue scale, algometer) and blood analyses (Interleukin-1, Interleukin-6, Interleukin-10, tumour necrosis factor-α, C-reactive protein, myoglobin, creatine kinase) were assessed at 7 time points over 5 days (pre, post, 4, 24, 48, 72 and 96h after the downhill run).

RESULTS:

No statistically significant differences were identified in any parameters between the active and placebo groups at any time point.

CONCLUSION:

After 2 months ingestion of Lyprinol(®) at the currently recommended dosage (200mg/day) and a demanding eccentric exercise intervention, Lyprinol(®) did not convincingly affect DOMS and indicators of muscle damage.

• Authors: Kate L Pumpa, Kieran E Fallon, Alan Bensoussan, Shona Papalia
• Journal: Complementary therapies in medicine (Complement Ther Med) Vol. 19 Issue 6 Pg. 311-8 (Dec 2011) ISSN: 1873-6963 [Electronic] Scotland
• PMID: 22036523 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Ltd. All rights reserved.

Chemical References

• Inflammation Mediators
• Lipids
• Myoglobin
• lyprinol
• Creatine Kinase

Topics

• Adolescent
• Adult
• Animals
• Athletic Performance (physiology)
• Bivalvia (chemistry)
• Creatine Kinase (blood)
• Double-Blind Method
• Humans
• Inflammation Mediators (blood)
• Lipids (pharmacology, therapeutic use)
• Male
• Movement
• Muscle, Skeletal (drug effects, physiology)
• Musculoskeletal Diseases (blood, prevention & control)
• Musculoskeletal Pain (blood, prevention & control)
• Myoglobin (blood)
• Oxygen Consumption
• Pain Measurement
• Running (physiology)
• Treatment Outcome
• Young Adult