Abstract | OBJECTIVES: PATIENTS AND METHODS: A two-step survey (registration and follow-up) was held between July 2008 and January 2009. One hundred and sixty doctors included patients treated with LHRHa for prostate cancer. Then, a follow-up registry was implemented for patients who had been prescribed a 3- or 6-monthly LHRHa. RESULTS: Data analysis showed that the 1853 registered patients had a mean age of 75 years old. Time to diagnosis was 7 months. Among them, 26.4% had an N+ and/or M+ cancer. The most tumor node metastasis (TNM) stage represented was T3N0M0 with Gleason score 7. High prostate specific antigen (PSA) level and metastatic stage were the main motives for LHRHa prescription. Choice criteria for a 3 or a 6-monthly LHRHa were patient autonomy (3.2 vs 18.4%), age (27.2 vs 44%) and anxiety (28 vs 16.8%). Patients for 6-monthly LHRHa were likely to be with low urinary symptoms, older, less autonomous and less anxious. The reported advantage of the 3-monthly LHRHa was the high satisfying quality of medical follow-up. For the 6-monthly form, the advantages were the flexibility and the freedom to stop worrying about their cancer for up to 6 months. CONCLUSION: The 6-monthly LHRHa provides more flexibility in the management and follow-up of patients with locally advanced or metastatic prostate cancer.
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Authors | I Ouzaid, M Rouprêt |
Journal | Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie
(Prog Urol)
Vol. 21
Issue 12
Pg. 866-74
(Nov 2011)
ISSN: 1166-7087 [Print] France |
Vernacular Title | Intérêt d'une forme semestrielle d'hormonothérapie pour le traitement du cancer de la prostate hormono-dépendant à un stade avancé : résultats d'ELIRE, enquête observationnelle française. |
PMID | 22035913
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Copyright | Copyright © 2011 Elsevier Masson SAS. All rights reserved. |
Chemical References |
- Antineoplastic Agents, Hormonal
- Biomarkers
- Delayed-Action Preparations
- luprolide acetate gel depot
- Gonadotropin-Releasing Hormone
- Prostate-Specific Antigen
- Leuprolide
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Topics |
- Aged
- Aged, 80 and over
- Antineoplastic Agents, Hormonal
(administration & dosage, therapeutic use)
- Biomarkers
(blood)
- Delayed-Action Preparations
- Follow-Up Studies
- France
- Gonadotropin-Releasing Hormone
(analogs & derivatives)
- Health Care Surveys
- Humans
- Leuprolide
(administration & dosage, therapeutic use)
- Male
- Neoplasm Grading
- Neoplasm Staging
- Neoplasms, Hormone-Dependent
(blood, drug therapy, pathology)
- Prostate-Specific Antigen
(blood)
- Prostatic Neoplasms
(blood, drug therapy, pathology)
- Quality of Life
- Surveys and Questionnaires
- Treatment Outcome
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