Bazedoxifene: a review of its use in the treatment of postmenopausal osteoporosis.

Abstract

Bazedoxifene (Conbriza®, Viviant®) is the first third-generation selective estrogen receptor modulator (SERM) and it is approved for the treatment of postmenopausal osteoporosis in the EU and Japan. Bazedoxifene contains an indole-based core binding domain that binds with high affinity to estrogen receptors and exhibits favourable effects on bone and lipid profiles, with no clinically relevant endometrial or breast stimulation. Oral bazedoxifene once daily reduced the incidence of new vertebral fractures in patients with postmenopausal osteoporosis in a large, well designed trial of 3 years' duration; both bazedoxifene and raloxifene were significantly more effective than placebo. Neither bazedoxifene nor raloxifene reduced the incidence of nonvertebral fractures in the overall study population; however, bazedoxifene, but not raloxifene, reduced the rate of nonvertebral fractures in high-risk patients. Moreover, data from patients who continued to receive the drug during a 2-year extension phase of this trial indicate that bazedoxifene continues to provide protection against new vertebral fractures for up to 5 years. Bazedoxifene also increases bone mineral density and reduces the levels of bone turnover markers. Bazedoxifene was generally well tolerated and did not detrimentally affect the reproductive tract or breast tissue in clinical trials, thereby demonstrating a favourable risk-benefit profile. A pharmacoeconomic analysis conducted from an EU perspective predicted bazedoxifene to be cost effective in some EU countries. Therefore, bazedoxifene presents another useful option for the treatment of postmenopausal osteoporosis, especially in those at high risk for osteoporotic fracture.

• Authors: Sean T Duggan, Kate McKeage
• Journal: Drugs (Drugs) Vol. 71 Issue 16 Pg. 2193-212 (Nov 12 2011) ISSN: 1179-1950 [Electronic] New Zealand
• PMID: 22035517 (Publication Type: Journal Article, Review)

Chemical References

• Bone Density Conservation Agents
• Indoles
• Selective Estrogen Receptor Modulators
• bazedoxifene

Topics

• Bone Density
• Bone Density Conservation Agents (therapeutic use)
• Female
• Humans
• Indoles (therapeutic use)
• Osteoporosis, Postmenopausal (drug therapy)
• Randomized Controlled Trials as Topic
• Selective Estrogen Receptor Modulators (therapeutic use)
• Treatment Outcome