Through the Danish National Hospital Register, we identified all 25 159 patients with isolated CABG from 1997 through 2006.
Stroke, comorbidities, and medication were further obtained. Risk factors of
stroke were determined through regression models.
RESULTS: Overall, 1901 patients (7.6%) suffered a
stroke after surgery, 477 patients (2.0%) within 30 days after CABG. Rates of
stroke per 100 person-years (95% CI) within 30 days after surgery increased with age: <60 years, 10.1 (7.8-13.0); 60 to 64 years, 18.4 (14.3-23.5); 65 to 69 years, 27.7 (23.0-33.3); 70 to 74 years, 36.0 (30.4-42.6); 75 to 79 years, 36.1 (29.1-44.7); ≥80 years, 38.0 (25.2-57.1). Risks of
stroke within 30 days after surgery adjusted for age (reference: age <60 years), sex, relevant comorbidities, and selected medication included: 60 to 64 years: HR, 1.7 (P=0.005; 95% CI, 1.2-2.4), 65 to 69 years: HR, 2.4 (P=0.001; 95% CI, 1.7-3.3), 70 to 74 years: HR, 2.8 (P=0.001; 95% CI, 2.1-3.8), 75 to 79 years: HR, 2.8 (P=0.001; 95% CI, 2.0-4.0), ≥80 years: HR, 3.0 (P=0.001; 95% CI, 1.8-4.9), previous
stroke: HR, 4.2 (P=0.001; 95% CI, 3.3-5.4), diabetes: HR, 1.3 (P=0.019; 95% CI, 1.1-1.7),
hypertension: HR, 1.4 (P=0.003; 95% CI, 1.1-1.7),
peripheral vascular disease: HR, 1.6 (P=0.001; 95% CI, 1.3-2.1),
renal failure: HR, 1.7 (P=0.012; 95% CI, 1.1-2.5),
statins: HR, 0.8 (P=0.049; 95% CI, 0.7-1.0),
clopidogrel: HR, 0.6 (P=0.032; 95% CI, 0.4-1.0).
CONCLUSIONS: