[Relapsed stage I neuroblastoma successfully treated by allogeneic bone marrow transplantation in second remission: case report of a 7-year-old girl].

Abstract

Stage I neuroblastoma in a seven-year-girl have had local recurrence with bone metastasis. Second surgery was performed after the aggressive chemotherapy including cisplatin, VP16, cyclophosphamide, vincristine and doxorubicin. She underwent allogeneic bone marrow transplantation from her HLA identical brother, following the preparative regimen consisting of high-dose melphalan and total body irradiation (12 Gy). Clinical course after the transplantation was uneventful. She is still alive with no evidence of disease for twenty-eight months after the transplantation. It is suggested that bone marrow transplantation is an effective way of therapy even in a patient with relapsed neuroblastoma.

• Authors: R Hanada, A Yaginuma, Y Hayashi, T Inaba, K Yamamoto, S Imaizumi, A Hirata, T Sugawara, T Aihara, T Miyakawa
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 17 Issue 9 Pg. 1937-9 (Sep 1990) ISSN: 0385-0684 [Print] Japan
• PMID: 2203317 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Etoposide
• Doxorubicin
• Cyclophosphamide
• Melphalan

Topics

• Adrenal Gland Neoplasms (pathology)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bone Marrow Transplantation
• Bone Neoplasms (drug therapy, secondary, surgery)
• Child
• Combined Modality Therapy
• Cyclophosphamide (administration & dosage)
• Doxorubicin (administration & dosage)
• Etoposide (administration & dosage)
• Female
• Humans
• Melphalan (administration & dosage)
• Neuroblastoma (drug therapy, secondary, surgery)
• Remission Induction
• Whole-Body Irradiation