Abstract | OBJECTIVE: METHOD: Thirty BALB/c mice were randomly divided into three groups, control group, allergic rhinitis group, and therapy group. The allergic rhinitis model was induced by classical method with ovalbumin. The therapy group was treated with IL-17 antibody. The concentration of IL-17, IL-4 and IFN-gamma in serum was measured by enzyme-linked immunosorbent assay (ELISA). Nasal mucosal inflammation was evaluated by HE staining. The expression of RORgammat mRNA was measured by reverse transcription-polymerase chain reaction (RT-PCR). RESULTS: The expression level of IL-17, IL-4 and RORgammat mRNA in allergic rhinitis group were significantly higher than those of control group and IL-17 antibody treated group (P < 0.05). While the expression level of IFN-gamma in allergic rhinitis group were significantly was lower than those of control group and IL-17 antibody treated group (P < 0.05). The inflammation reaction in therapy group abated with nasal mucosal HE staining. CONCLUSION:
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Authors | Min Shi, Hui Huangfu, Chunming Zhang, Qingli Huang, Min Zhang, Yangzi Jin |
Journal | Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
(Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi)
Vol. 25
Issue 14
Pg. 652-5
(Jul 2011)
ISSN: 2096-7993 [Print] China |
PMID | 22032125
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Interleukin-17
- Interleukin-4
- Interferon-gamma
- Ovalbumin
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Topics |
- Animals
- Disease Models, Animal
- Female
- Interferon-gamma
(immunology)
- Interleukin-17
(immunology)
- Interleukin-4
(immunology)
- Male
- Mice
- Mice, Inbred BALB C
- Ovalbumin
(immunology)
- Rhinitis
(immunology, metabolism)
- Th17 Cells
(immunology)
- Th2 Cells
(immunology)
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