Abstract | BACKGROUND AND OBJECTIVE: MATERIAL AND METHODS: Plaque samples from subjects without (n = 18) and with moderate to advanced periodontitis (n = 41) were used to quantify P. gingivalis using real-time PCR. Protease inhibitor levels in the gingival crevicular fluid of all the subjects were determined by ELISA. RESULTS: CONCLUSION: The reduced concentrations of SLPI and ELAFIN may contribute to the loss of host protective capacity and increase susceptibility to breakdown from chronic infection. The work of this investigation may aid in finding diagnostic and prognostic markers in periodontal health and disease and may also help in finding pharmacological targets directed against periodontal inflammation.
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Authors | S Kretschmar, L Yin, F Roberts, R London, T T Flemmig, D Arushanov, K Kaiyala, W O Chung |
Journal | Journal of periodontal research
(J Periodontal Res)
Vol. 47
Issue 2
Pg. 228-35
(Apr 2012)
ISSN: 1600-0765 [Electronic] United States |
PMID | 22029638
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © 2011 John Wiley & Sons A/S. |
Chemical References |
- Antigens, Neoplasm
- Elafin
- Protease Inhibitors
- Secretory Leukocyte Peptidase Inhibitor
- Serpins
- squamous cell carcinoma-related antigen
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Topics |
- Adult
- Antigens, Neoplasm
(analysis)
- Bacterial Load
- Chronic Periodontitis
(enzymology, microbiology)
- Dental Plaque
(microbiology)
- Dental Plaque Index
- Elafin
(analysis)
- Female
- Gingival Crevicular Fluid
(enzymology)
- Gingival Hemorrhage
(enzymology, microbiology)
- Humans
- Male
- Middle Aged
- Periodontal Attachment Loss
(enzymology, microbiology)
- Periodontal Index
- Periodontal Pocket
(enzymology, microbiology)
- Periodontium
(enzymology)
- Porphyromonas gingivalis
(growth & development)
- Protease Inhibitors
(analysis)
- Secretory Leukocyte Peptidase Inhibitor
(analysis)
- Serpins
(analysis)
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