Abstract |
The molecular recognition of dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin ( DC-SIGN) with arthropod-derived N- glycans on E- glycoprotein is essential for dengue virus (DENV) infection in humans. Therefore, the specific interaction of DC-SIGN with N- glycans on E- glycoprotein is a promising target for development of virus replication inhibitors. This article discusses the findings of a recent report describing antiviral activities of carbohydrate-binding agents, such as lectins and a small molecular weight compound against DENV infection of monocyte-derived dendritic cells. Several plant lectins and the small molecular weight compound Pladimicin-S showed potent inhibition of cellular infection by four DENV serotypes.
|
Authors | Kazuya I P J Hidari, Takashi Suzuki |
Journal | Expert review of anti-infective therapy
(Expert Rev Anti Infect Ther)
Vol. 9
Issue 11
Pg. 983-5
(Nov 2011)
ISSN: 1744-8336 [Electronic] England |
PMID | 22029517
(Publication Type: Comment, Journal Article)
|