[Seroconversion and immune response after anti-HBV vaccination in patients on chronic hemodialysis: comparison of two vaccines].

ESRD patients on hemodialysis (HD) have a high risk of HBV infections. Primary prevention through vaccination is a first choice to reduce the morbidity from HBV. Prevention can be accomplished by two types of vaccines. The aim of this study was to evaluate the serological response to HBV vaccination in a population of HD patients who were randomized to Fendrix or Engerix B according to common administration protocols. Ninety-two HD patients were randomized to Fendrix or Engerix B immunization protocols. Patients in the Fendrix arm received four intramuscular administrations of 20 micron g, while patients in the Engerix arm received three intramuscular administrations of 40 micron g with an optional booster dose at two months from the last administration in nonresponders. The seroconversion rates were higher in the Fendrix group than the Engerix group, with faster responses, higher titers and longer duration of immune memory. Fendrix seems to be more effective than the older vaccine, Engerix, especially in patients at high infection risk like those making up our study population. Other crucial factors for good outcomes in patient immunization were biological and dialysis age. This underlines the importance of early immunization protocols such as already discussed by many nephrologists.
AuthorsPasquale Polito, Luca Di Lullo, Giuseppe Roberto Iannacci, Annalisa Cecilia, Cristina Galderisi, Antonio Gorini
JournalGiornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia (G Ital Nefrol) 2011 Sep-Oct Vol. 28 Issue 5 Pg. 525-30 ISSN: 0393-5590 [Print] Italy
Vernacular TitleSieroconversione e risposta immunitaria dopo vaccinazione anti-HBV in pazienti sottoposti a trattamento emodialitico cronico: confronto tra due diversi protocolli di vaccinazione.
PMID22028266 (Publication Type: Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)
Chemical References
  • Engerix-B
  • Fendrix
  • Hepatitis B Antibodies
  • Hepatitis B Vaccines
  • Vaccines, Synthetic
  • Aged
  • Aged, 80 and over
  • Catheters, Indwelling
  • Female
  • Hepatitis B (prevention & control, transmission)
  • Hepatitis B Antibodies (biosynthesis)
  • Hepatitis B Vaccines (immunology)
  • Humans
  • Immunocompromised Host
  • Immunologic Memory
  • Kidney Failure, Chronic (complications, immunology, therapy)
  • Male
  • Middle Aged
  • Renal Dialysis (adverse effects)
  • Vaccination
  • Vaccines, Synthetic (immunology)

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