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The molecular role of Fra-1 and its prognostic significance in human esophageal squamous cell carcinoma.

AbstractBACKGROUND:
The expression of Fra-1 (Fos related antigen 1) involves tumor progression and invasion, and its gene ablation could suppress the invasive phenotypes of human tumor cells. The authors investigated the significance of Fra-1 expression in esophageal squamous cell carcinoma (ESCC) and studied the effect of its down-regulation on cell proliferation, motility, and invasion.
METHODS:
Surgical specimens from 164 patients with ESCC were evaluated. Fra-1 expression in the primary tumor along with metastatic lymph nodes was compared among various clinicopathological characteristics, and overall survival was analyzed. The rate and intensity of Fra-1 immunoreactivity were also investigated. The molecular role of Fra-1 was assessed by its down-regulation in human ESCC cell lines.
RESULTS:
Fra-1 expression was positive in 127 (77.4%) ESCC patients. Immunoreactivity was localized to the marginal areas of the ESCC tumors. Positive Fra-1 expression correlated with depth of tumor, lymph node metastasis, stage, and infiltrative growth pattern. A significant difference was seen in the survival between tumors with and without Fra-1, and positive Fra-1 expression was revealed to be an independent factor related to poor prognosis. Patients with metastatic lymph nodes with positive Fra-1 expression presented decreased survival compared with negative Fra-1 expression. After the down-regulation of Fra-1 expression, a significant decrease in cell proliferation, motility, and invasion was observed.
CONCLUSIONS:
This study demonstrated ESCC patients positive for Fra-1 to be associated with poor prognosis. The findings also suggest that Fra-1 regulation may play an important role in the progression of ESCC.
AuthorsAkihiro Usui, Isamu Hoshino, Yasunori Akutsu, Haruhito Sakata, Takanori Nishimori, Kentaro Murakami, Masayuki Kano, Kiyohiko Shuto, Hisahiro Matsubara
JournalCancer (Cancer) Vol. 118 Issue 13 Pg. 3387-96 (Jul 01 2012) ISSN: 1097-0142 [Electronic] United States
PMID22028113 (Publication Type: Journal Article)
CopyrightCopyright © 2011 American Cancer Society.
Chemical References
  • Proto-Oncogene Proteins c-fos
  • fos-related antigen 1
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Squamous Cell (genetics, pathology)
  • Cell Line, Tumor
  • Cell Movement (genetics)
  • Cell Proliferation
  • Disease Progression
  • Down-Regulation
  • Esophageal Neoplasms (genetics, pathology)
  • Female
  • Humans
  • Lymphatic Metastasis (genetics)
  • Male
  • Middle Aged
  • Neoplasm Invasiveness
  • Prognosis
  • Proto-Oncogene Proteins c-fos (genetics)
  • Survival Analysis

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