Abstract | AIM: METHODS: RESULTS:
Ezetimibe treatment significantly reduced serum levels of low-density lipoprotein cholesterol ( LDL-C) and malondialdehyde-modified low-density lipoprotein (MDA- LDL). In addition, the values of body mass index, body weight, waist circumference, plasma HbA1c and urinary albumin were significantly decreased in group E compared to those in group C. On the other hand, high-density lipoprotein cholesterol (HDL-C) and adiponectin levels were significantly increased in group E compared to those in group C. The values of brachial-ankle pulse wave velocity (ba-PWV), mean arterial blood pressure (m-ABP), and % of flow-mediated dilation (FMD) were significantly improved in group E. Furthermore, ultrasonic studies demonstrated amelioration of the vascular stiffness of common carotid arteries in group E but not in group C. These vascular protective effects of ezetimibe were statistically correlated with the decreased values of MDA- LDL and MDA- LDL-to- LDL-C ratio but not with those of LDL-C. CONCLUSION:
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Authors | Hirotsugu Kurobe, Ken-ichi Aihara, Mayuko Higashida, Yoichiro Hirata, Masako Nishiya, Yuki Matsuoka, Tamotsu Kanbara, Taisuke Nakayama, Hajime Kinoshita, Mikio Sugano, Eiki Fujimoto, Ayako Kurobe, Noriko Sugasawa, Takashi Kitaichi, Masashi Akaike, Masataka Sata, Toshio Matsumoto, Tetsuya Kitagawa |
Journal | Journal of atherosclerosis and thrombosis
(J Atheroscler Thromb)
Vol. 18
Issue 12
Pg. 1080-9
( 2011)
ISSN: 1880-3873 [Electronic] Japan |
PMID | 22027560
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Azetidines
- Lipids
- Ezetimibe
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Topics |
- Aged
- Azetidines
(pharmacology, therapeutic use)
- Case-Control Studies
- Endothelium, Vascular
(drug effects, physiopathology)
- Ezetimibe
- Humans
- Hypercholesterolemia
(physiopathology)
- Lipids
(blood)
- Male
- Middle Aged
- Oxidative Stress
(drug effects)
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