Synthesis of oxovanadium(IV) Schiff base complexes derived from C-substituted diamines and pyridoxal-5-phosphate as antitumor agents.

Abstract

Oxovanadium (IV) complexes of N,N'-bispyridoxyl-5, 5'-bis (phosphate) ethylenediimine (L1) and N,N'-bis(pyridoxyl)-5,5'-bis(phosphate)-1''-(p-nitrobenzyl)ethylenediimine (L2) were synthesized by condensation of optically active C-substituted diamines and pyridoxal-5-phosphate. Oxovanadium (IV) complexes derived from L1 and L2 were evaluated as DNA cleavage agent (cleavage of supercoiled plasmid pBR322 DNA). Interestingly, both the oxovanadium (IV) complexes exhibited DNA nuclease activity, and the extent of oxidation of DNA by these vanadyl complexes was superior to VOSO(4) . The significant reduction in primary tumor and increased delay in tumor growth of 15 days was seen in the tumor regression analysis with oxovanadium (IV) complex of L1. With the preliminary studies performed with the pyridoxal-5-phosphate -based salen derivatives including the cytotoxicity and tumor regression, it is evident that the salen bifunctional chelating agent has obtained therapeutic potential if conjugated to a gene-specific targeting molecule for the oxidation of guanine residue.

• Authors: Puja Panwar Hazari, Anand Kumar Pandey, Shubhra Chaturvedi, Anjani Kumar Tiwari, Sudhir Chandna, Bilikere Srinivasarao Dwarakanath, Anil Kumar Mishra
• Journal: Chemical biology & drug design (Chem Biol Drug Des) Vol. 79 Issue 2 Pg. 223-34 (Feb 2012) ISSN: 1747-0285 [Electronic] England
• PMID: 22023804 (Publication Type: Letter, Research Support, Non-U.S. Gov't)
• Copyright: © 2011 John Wiley & Sons A/S.

Chemical References

• Antineoplastic Agents
• Coordination Complexes
• Diamines
• Schiff Bases
• Vanadates
• Pyridoxal Phosphate
• DNA

Topics

• Animals
• Antineoplastic Agents (chemical synthesis, pharmacology)
• Carcinoma, Ehrlich Tumor (pathology)
• Cell Cycle Checkpoints (drug effects)
• Cell Line, Tumor
• Coordination Complexes (chemical synthesis, pharmacology)
• DNA (metabolism)
• DNA Cleavage (drug effects)
• Diamines (chemistry)
• Female
• Humans
• Mice
• Neoplasms (pathology)
• Oxidation-Reduction
• Pyridoxal Phosphate (chemistry)
• Schiff Bases (chemistry)
• Transplantation, Heterologous
• Vanadates (chemistry)