Abstract | BACKGROUND AND OBJECTIVES: MATERIALS AND METHODS: Six week old male Sprague-Dawley rats were treated, as follows: control group, subcutaneous (sc) injection of saline; M group, sc injection of M (60 mg/kg); and simvastatin group, sc injection of M (60 mg/kg) plus 10 mg/kg/day simvastatin orally. RESULTS: On day 28, right ventricular hypertrophy (RVH) significantly decreased in the simvastatin group compared to the M group. Similarly, right ventricular pressure significantly decreased in the simvastatin group on day 28. From day 7, the ratio of medial thickening of the pulmonary artery was significantly increased in the M group, but there was no significant change in the simvastatin group. The number of muscular pulmonary arterioles was significantly reduced in the simvastatin group. On day 5, gene expressions of ET-1, ERA, NOS2, NOS3, MMP and TIMP significantly decreased in the simvastatin group. CONCLUSION: Administration of simvastatin exerted weak inhibitory effects on RVH and on the number of muscular pulmonary arterioles, during the development of M-induced pulmonary hypertension in rats. Simvastatin decreased gene expressions on day 5.
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Authors | Yun Hee Lee, Kwan Chang Kim, Min-Sun Cho, Young Mi Hong |
Journal | Korean circulation journal
(Korean Circ J)
Vol. 41
Issue 9
Pg. 518-27
(Sep 2011)
ISSN: 1738-5555 [Electronic] Korea (South) |
PMID | 22022327
(Publication Type: Journal Article)
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