Antimicrobial efficacies of several antibiotics against uterine cervicitis caused by Mycoplasma genitalium.

Abstract

Mycoplasma genitalium has been shown to be one of the pathogens responsible for uterine cervicitis by many studies. However, there are no clinical recommendations for treating M. genitalium-positive uterine cervicitis. Our study retrospectively investigated the antimicrobial efficacies of several antibiotics against uterine cervicitis caused by M. genitalium. We studied a total of 257 women with M. genitalium-positive uterine cervicitis, except for those with chlamydial and gonococcal infections, who were treated with one of the following antibacterial therapies: azithromycin extended release formulation (AZM-SR) 2 g single dose, azithromycin (AZM) 1 g single dose, clarithromycin (CAM) 400 mg/day for 7 days, CAM 400 mg/day for 14 days, moxifloxacin (MFLX) 400 mg/day for 7 days, MFLX 400 mg/day for 14 days, levofloxacin (LVFX) 500 mg/day for 7 days, LVFX 500 mg/day for 14 days, sitafloxacin (STFX) 200 mg/day for 7 days, and STFX 200 mg/day for 14 days. A PCR-based assay was performed to evaluate the microbiological efficacy of eradication in these patients. M. genitalium was eradicated from the uterine cervix in 19 of the 21 (90.5%) patients treated with AZM-SR 2 g single dose, in 38 of the 42 (90.5%) patients treated with MFLX 400 mg/day for 7 days, in 42 of the 42 (100%) patients treated with MFLX 400 mg/day for 14 days, and in 12 of the 13 (92.3%) patients treated with STFX 200 mg/day for 14 days. In conclusion, AZM-SR 2 g single dose, MFLX 400 mg/day for 14 days, and STFX 200 mg/day for 14 days would each be an effective treatment for M. genitalium infection.

• Authors: Michinori Terada, Koji Izumi, Emiko Ohki, Yuka Yamagishi, Hiroshige Mikamo
• Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (J Infect Chemother) Vol. 18 Issue 3 Pg. 313-7 (Jun 2012) ISSN: 1437-7780 [Electronic] Netherlands
• PMID: 22020630 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Aza Compounds
• Fluoroquinolones
• Quinolines
• Azithromycin
• sitafloxacin
• Moxifloxacin

Topics

• Adolescent
• Adult
• Anti-Bacterial Agents (adverse effects, therapeutic use)
• Aza Compounds (adverse effects, therapeutic use)
• Azithromycin (adverse effects, therapeutic use)
• Female
• Fluoroquinolones (adverse effects, therapeutic use)
• Humans
• Microbial Sensitivity Tests
• Moxifloxacin
• Mycoplasma Infections (drug therapy, microbiology)
• Mycoplasma genitalium (genetics, isolation & purification)
• Polymerase Chain Reaction
• Quinolines (adverse effects, therapeutic use)
• Retrospective Studies
• Uterine Cervicitis (drug therapy, microbiology)