Abstract |
Twenty-one patients with postherpetic neuralgia of two- to 84-months duration participated in a double-blind, placebo-controlled study of oral acyclovir. Pain perception was assessed with the Melzack Pain Questionnaire at baseline and at two-to six-week intervals during the ensuing six months. Clinically significant pain reduction occurred in eight patients: four received acyclovir, and four received a placebo. Several treatment strategies have been advocated for relief of postherpetic neuralgia. Results of the present study demonstrate the need for a double-blind, placebo-controlled paradigm to substantiate the efficacy of new clinical approaches. The same caveat applies to the more common syndromes encountered in psychiatric practice.
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Authors | O S Surman, T Flynn, R T Schooley, L Baer, S Parker, M S Hirsch, L G Davis |
Journal | Psychosomatics
(Psychosomatics)
Vol. 31
Issue 3
Pg. 287-92
( 1990)
ISSN: 0033-3182 [Print] England |
PMID | 2201992
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Acyclovir
(administration & dosage)
- Administration, Oral
- Aged
- Aged, 80 and over
- Clinical Trials as Topic
- Double-Blind Method
- Female
- Herpes Zoster
(drug therapy)
- Humans
- Male
- Middle Aged
- Neuralgia
(drug therapy)
- Pain Measurement
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