[Research on patulin biosynthesis and infection of Chinese medicinal materials by its producing strains].

Abstract

OBJECTIVE:

To investigate the effect of patulin producing strains on the different Chinese medicinal materials and the toxin biosynthesis mechanism.

METHOD:

Microbiology and HPLC analytical methods were adopted in this paper.

RESULT:

It was showed that the materials rich in starch and other polysaccharides were easily polluted by the patulin producing strain. This strain grew well and produced more toxins under 25 degrees C, 95% moisture content and bulk package. And the effect of low illumination intensity on the strain growth and toxin biosynthesis was not notable. Sample stability, precision, repeatability and rate of recovery were studied. HPLC analytic method was established and it revealed that the test method was suitable.

CONCLUSION:

The pollution of Chinese medicinal materials by toxin producing microbes will be effectively controlled through establishing the suitable storage methods. So the study on the growing characteristics and toxin biosynthesis mechanism of toxin producing strains will be an important practical significance for controlling the toxin pollution of herbal medicines and contribute to establish the evaluation system of Chinese medicine safety.

• Authors: Shu Jiang, Meihua Yang, Jin'ao Duan, Jinhua Tao, Dawei Qian
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 36 Issue 14 Pg. 1936-40 (Jul 2011) ISSN: 1001-5302 [Print] China
• PMID: 22016963 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drugs, Chinese Herbal
• Patulin

Topics

• Drug Compounding (standards)
• Drug Contamination (prevention & control)
• Drugs, Chinese Herbal (adverse effects, standards)
• Fungi (growth & development, metabolism)
• Patulin (biosynthesis)
• Quality Control
• Safety