[Reactive oxygen species and 3,4-dihydroxyphenylacetaldehyde in pathogenesis of Parkinson disease].

Abstract

Reactive oxygen species, which plays a role in pathogenesis of many neurodegenerative diseases, seems to be important also in pathogenesis of the Parkinson's disease. Experiments performed recently, revealed in the cerebrum of patients suffering from this disease (induced by the oxidative stress) elevated levels of 3,4-dihydroxyphenylacetaldehyde (DOPAL)--a strong endogenous neurotoxin to dopamine neurons.

• Authors: Iwona Rybakowska, Grzegorz Szreder, Krystian Kaletha, Małgorzata Barwina, Wojciech Waldman, Jacek Sein Anand
• Journal: Przeglad lekarski (Przegl Lek) Vol. 68 Issue 8 Pg. 486-7 ( 2011) ISSN: 0033-2240 [Print] Poland
• Vernacular Title: Reaktywne formy tlenu i aldehyd 3,4-dihydroksyfenylooctowy w patogenezie choroby Parkinsona.
• PMID: 22010445 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Reactive Oxygen Species
• 3,4-Dihydroxyphenylacetic Acid
• 3,4-dihydroxyphenylacetaldehyde

Topics

• 3,4-Dihydroxyphenylacetic Acid (analogs & derivatives, metabolism)
• Brain (metabolism)
• Humans
• Oxidative Stress
• Parkinson Disease (etiology, metabolism)
• Reactive Oxygen Species (metabolism)