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Granulocyte and monocyte adsorption apheresis as an effective treatment for Reiter disease.

Abstract
Reiter disease (RD) is characterized by a triad of sterile arthritis, urethritis and conjunctivitis. The conditions occur concomitantly or sequentially, and are associated with mucocutaneous features such as circinate balanitis and stomatitis. Arthritis usually occurs in attacks followed by recovery, but it sometimes progresses to permanent damage of the affected joints. Because the symptoms of this disorder are attributable to activated neutrophils, we assessed the efficacy of granulocyte and monocyte adsorption apheresis (GCAP) in a 73-year-old man with RD who had skin rashes on his penis, scrotum and right hand, with severe arthralgia. The patient's skin rash and joint pain responded dramatically to five sessions of GCAP delivered at intervals of 5 days. We present a detailed description of the patient and discuss the mechanisms of GCAP, and suggest that GCAP may be useful for treating RD.
AuthorsA Yoshifuku, K Oyama, A Ibusuki, M Kawasaki, M Sakanoue, S Matsushita, K Kawai, K Kawahara, I Maruyama, T Kanekura
JournalClinical and experimental dermatology (Clin Exp Dermatol) Vol. 37 Issue 3 Pg. 241-4 (Apr 2012) ISSN: 1365-2230 [Electronic] England
PMID22007878 (Publication Type: Case Reports, Journal Article)
Copyright© The Author(s). CED © 2011 British Association of Dermatologists.
Topics
  • Adsorption
  • Aged
  • Arthritis, Reactive (therapy)
  • Genital Diseases, Male (etiology, therapy)
  • Humans
  • Leukapheresis (methods)
  • Male
  • Skin Diseases, Papulosquamous (etiology, therapy)
  • Treatment Outcome

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