Abstract |
The aim of this study is to investigate the antitumour and antioxidant activities of the ethanol extract of Scutia myrtina (EESM) against Ehrlich's ascites carcinoma (EAC) in mice. Twenty-four hours after tumour inoculation, EESM was administered at doses 100, 200 and 300 mg kg⁻¹ bodyweight/mice/day for 21 days. EESM caused a significant (p < 0.01) decrease in ascites volume, packed cell volume and viable cell count, and also prolonged the life span of EAC tumour-bearing mice. Haematological profiles reverted to near-normal levels in extract-treated mice (p < 0.01). EESM also produced protective effects by significantly decreasing the activity of serum enzymes and bilirubin and increasing the protein and uric acid levels (p < 0.05). EESM significantly (p < 0.05) decreased the levels of lipid peroxidation, while it significantly (p < 0.05) increased the levels of enzymatic and non-enzymatic antioxidants. The results indicate that EESM exhibited significant antitumour and antioxidant activities in EAC-bearing mice.
|
Authors | Ramanathan Sambath Kumar, Kupusamy Asok Kumar, Nallasamy Venkateswara Murthy |
Journal | Natural product research
(Nat Prod Res)
Vol. 26
Issue 16
Pg. 1504-9
( 2012)
ISSN: 1478-6427 [Electronic] England |
PMID | 22007751
(Publication Type: Journal Article)
|
Chemical References |
- Antineoplastic Agents, Phytogenic
- Antioxidants
|
Topics |
- Animals
- Antineoplastic Agents, Phytogenic
(therapeutic use)
- Antioxidants
(therapeutic use)
- Carcinoma, Ehrlich Tumor
(drug therapy)
- Cell Line, Tumor
- Humans
- Lipid Peroxidation
(drug effects)
- Male
- Mice
- Rhamnaceae
(chemistry)
- Xenograft Model Antitumor Assays
|